Biosynthetic growth hormone therapy in children with growth hormone deficiency: experience at AIIMS, New Delhi.
Indian J Pediatr
;
1991 Sep-Oct; 58 Suppl 1(): 71-7
Article
in English
| IMSEAR
| ID: sea-84746
ABSTRACT
A total of 20 previously untreated children with growth hormone deficiency (GHD) were treated for one year with biosynthetic human growth hormone (hGH). The mean chronologic age was 9.43 +/- 3.52 years with a height age of 5.02 years, and bone age 9.43 +/- 3.52 (TW2-RUS) 6.42 years. The mean pretreatment growth velocity was 2.43 +/- 0.90 cm/year. Of these 14 children had complete GHD (peak GH levels less than 5 ng/ml) and 6 had partial GHD. They were treated with recombinant GH in a dose of 0.5 IU/kg/week divided into 6-7 injections per week subcutaneously at night. The mean growth velocity increased to 8.88 +/- 2.10 cm/yr at the end of 6 months and 8.00 +/- 2.21 cm/yr at 12 months. The actual gain ranged from 6-11 cm in a year. There were no local adverse reactions. One child developed vitiligo of the face and another transient hyperglycemia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Time Factors
/
Body Height
/
Recombinant Proteins
/
Female
/
Humans
/
Male
/
Growth Hormone
/
Child
/
Anthropometry
/
Academies and Institutes
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pediatr
Year:
1991
Type:
Article
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