Per rectal diazepam therapy in convulsive disorders.
Indian Pediatr
;
1992 Aug; 29(8): 975-8
Article
in English
| IMSEAR
| ID: sea-8552
ABSTRACT
One hundred and twenty children with persistent convulsions (lasting > or = 10 min) were treated with per rectal diazepam (dosage 0.2 to 0.7 mg/kg/dose). Another group of 100 age matched children with convulsions, along with those who did not respond to rectal therapy were given intravenous diazepam in a dosage of 0.2 to 0.3 mg/kg/dose. Rectal treatment was effective in 80.83% cases while intravenous diazepam was effective in 90% cases which is statistically just significant (p < 0.05). No significant difference was observed in the efficacy of two routes of administration in controlling convulsions of different clinical types and various etiological groups (p < 0.05), except for primary generalized type where intravenous route was more effective than the rectal one (p < 0.05). No significant side-effect was observed with rectal therapy. Among the 23 (19.17%) children in whom rectal therapy failed, 12 (10%) responded to intravenous diazepam while the remaining 11 (9.17%) cases were resistant to both routes of administration.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Seizures
/
Administration, Rectal
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Child
/
Child, Preschool
/
Treatment Outcome
/
Diazepam
Language:
English
Journal:
Indian Pediatr
Year:
1992
Type:
Article
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