Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil.
J Health Popul Nutr
;
2003 Dec; 21(4): 309-15
Article
in English
| IMSEAR
| ID: sea-857
ABSTRACT
To examine the association of intestinal barrier function with vitamin A deficiency and whether supplementation of micronutrients improves intestinal function and/or linear growth, height-for-age z-score (HAZ), concentrations of serum retinol and zinc, and intestinal permeability were determined in a cross-sectional sample of 75 children in northeastern Brazil. Effects of vitamin A and supplementation of zinc on intestinal permeability and growth were also determined comparing results before and after treatment in 20 children and age-matched controls. Lactulosemannitol (L/M) permeability ratios inversely correlated with serum retinol concentrations (r = -0.55, p < 0.0005). Increased L/M permeability ratios with reduced concentrations of serum retinol were predominantly attributable to lower absorption of mannitol (r = 0.28, p = 0.02). L/M permeability ratios (p = 0.001) and HAZ scores (p = 0.007) improved with supplementation. It is concluded that impaired intestinal barrier function and linear growth shortfalls improve following supplementation of vitamin A and zinc in this setting.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vitamin A
/
Vitamin A Deficiency
/
Zinc
/
Brazil
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Capillary Permeability
/
Child Nutritional Physiological Phenomena
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J Health Popul Nutr
Journal subject:
Gastroenterology
/
Nutritional Sciences
/
Public Health
Year:
2003
Type:
Article
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