A comparison of low vs standard dose intramuscularly administered hepatitis B vaccine.
Article
in English
| IMSEAR
| ID: sea-86195
ABSTRACT
In a randomised, controlled, single-blind trial we compared different doses of a yeast-derived recombinant hepatitis B vaccine a low dose intramuscular (i.m.) regimen (using 2 micrograms at first followed by 1 microgram each at 1, 2 and 6 months) with the standard dose (10 micrograms each at 0, 1 and 6 months) for post vaccination anti-HBs seropositivity. At the end of 7 months, only 78% of volunteers on the low dose (n = 77) tested positive for anti-HBs whereas 100% of volunteers on the standard dose (n = 43) were seropositive. Therefore, low dose regimen is not satisfactory for primary HBV vaccination.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Single-Blind Method
/
Hepatitis B Vaccines
/
Adult
/
Dose-Response Relationship, Drug
/
Hepatitis B
/
Hepatitis B Antibodies
/
Injections, Intramuscular
Type of study:
Controlled clinical trial
Language:
English
Year:
1994
Type:
Article
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