Pancreatic xenograft survival in diabetic rabbits.
Article
in English
| IMSEAR
| ID: sea-86934
ABSTRACT
Prolonged survival of pancreatic xenografts in the muscles of diabetic rabbits was achieved. The mean graft survival time (assessed by euglycemic status) in nonimmunosuppressed (Group A) was 10 days and in immunosuppressed (Group B) was 36 days (P < 0.05). Adequate immunosuppression helps pancreatic xenograft to normalize blood glucose level (BGL) by prolonging survival time. Our study demonstrates that xenotransplantation of islet cells in their natural environment (pancreatic tissue in four of thin slices) survive and function adequately in immunosuppressed recipients. This discordant Xenotransplantation model may be useful for future xenotransplantation studies.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Time Factors
/
Transplantation, Heterologous
/
Blood Glucose
/
Goats
/
Immunosuppression Therapy
/
Pancreas Transplantation
/
Diabetes Mellitus, Experimental
/
Graft Survival
/
Animals
Type of study:
Prognostic study
Language:
English
Year:
1994
Type:
Article
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