Magnesium deficiency potentiates free radical production associated with myocardial infarction.
Article
in English
| IMSEAR
| ID: sea-87369
ABSTRACT
OBJECTIVE:
Oxidative injury and magnesium deficiency may accompany cardiovascular disease states and the study was planned to find out whether magnesium deficiency promotes oxidative injury.METHODS:
Serum malonaldehyde (MDA), magnesium, vitamin E and total glutathione levels (GSH) were estimated in 22 patients with acute myocardial infarction and 15 healthy controls.RESULTS:
Low levels of Mg, GSH, vitamin E and elevated levels of MDA were observed in patients of acute myocardial infarction. Statistically significant correlations were observed between Mg and MDA, MDA and GSH, Mg and vitamin E.CONCLUSION:
Our findings suggest that Mg deficiency can potentiate oxidative injury to post ischaemic myocardium and that antioxidants may have a role in protection against the prooxidant influence(s) of Mg deficiency.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vitamin E
/
Aged
/
Female
/
Humans
/
Male
/
Risk Factors
/
Reactive Oxygen Species
/
Free Radicals
/
Glutathione
/
Magnesium
Type of study:
Etiology study
/
Risk factors
Language:
English
Year:
2000
Type:
Article
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