The activity of superoxide dismutase in hydroxyurea-treated E beta thalassemia.
Article
in English
| IMSEAR
| ID: sea-87828
ABSTRACT
AIM:
To study the activity of superoxide dismutase (SOD) and the level of fetal hemoglobin (HbF) in hydroxyurea (HU)-treated E beta thalassaemia.METHODS:
We have measured SOD level, HbF, mean corpuscular volume (MCV), packed cell volume (PCV) and hemoglobin (Hb) of E beta thalassaemia treated with HU (dose 30 mg/kg/day) for consecutive 90 days.RESULT:
The increase of HbF synthesis without increase of Hb was observed in HU-treated patients.CONCLUSION:
The decreased SOD level in long term and low dose of HU therapy in E beta thalassaemia may have some role to inhibit superoxide radical of erythrocyte. HU may act as inhibitor for oxidative damage of red cell in E beta thalassaemia.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Superoxide Dismutase
/
Humans
/
Fetal Hemoglobin
/
Adolescent
/
Beta-Thalassemia
/
Hydroxyurea
/
Antisickling Agents
Language:
English
Year:
2002
Type:
Article
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