Lipid peroxide levels in chronic renal failure.
Article
in English
| IMSEAR
| ID: sea-88778
ABSTRACT
To determine presence of oxidant stress in chronic renal failure and to evaluate the efficacy of vitamin E in its amelioration, we studied 34 patients (Group I, age 32.4 +/- 11 years, MF 31) and 10 healthy controls (Group II, age 27.4 +/- 5 years, MF 41). The difference in baseline values of lipid peroxide (nmol/ml) was statistically significant (Group I 4.19 +/- 1.69, Group II 1.87 +/- 1.39, p = 0.004). Values of vitamin E (mg/l) were also significantly lower in Group I as compared to Group II (12.18 +/- 4.27 vs. 19.32 +/- 2.03, p = 0.003). Serum lipid peroxide values decreased significantly after supplementation with 400 mg/day of vitamin E for six weeks in Group I (4.19 +/- 1.69 to 3.21 +/- 1.13, p = 0.053) but not in Group II (1.87 +/- 1.39 to 1.03 +/- 0.87). Levels of vitamin E increased in both the groups (Group I 12.18 +/- 4.27 to 16.01 +/- 5.13, Group II 19.32 +/- 2.03 to 23.21 +/- 1.94, p < 0.005). No significant difference was observed in values of serum creatinine and urea before and after intervention.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Reference Values
/
Vitamin E
/
Female
/
Humans
/
Male
/
Follow-Up Studies
/
Adult
/
Dietary Supplements
/
Kidney Failure, Chronic
/
Kidney Function Tests
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Language:
English
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS