Double blind, placebo controlled trial on the cytoprotective effect of misoprostol in subjects with rheumatoid arthritis, osteoarthritis and seronegative spondarthropathy on NSAIDs.
Article
in English
| IMSEAR
| ID: sea-89113
ABSTRACT
Ninety arthritic patients were randomly allotted to receive misoprostol 200 micrograms thrice daily or placebo, for 4 weeks, while they were started on various NSAIDs. While upper gastrointestinal symptoms occurred equally in both groups, patients on placebo had significantly more post-therapy abnormal endoscopy findings. Misoprostol was well tolerated without any adverse side effects; it did not interfere with the therapeutic efficacy of the NSAIDs. Arthritic patients requiring long term NSAID therapy appear to benefit from misoprostol because of its cytoprotective effect on the gastrointestinal mucosa.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Osteoarthritis
/
Peptic Ulcer
/
Arthritis, Rheumatoid
/
Spondylitis, Ankylosing
/
Female
/
Humans
/
Male
/
Anti-Inflammatory Agents, Non-Steroidal
/
Double-Blind Method
/
Misoprostol
Type of study:
Controlled clinical trial
Language:
English
Year:
1991
Type:
Article
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