Effects of commonly used NSAID's on gastric mucosa. A clinico-endoscopic and histopathological study.
Article
in English
| IMSEAR
| ID: sea-89428
ABSTRACT
Non steroidal anti-inflammatory drugs (NSAID's) are one of the most commonly used agents in clinical practice today. All these drugs are known to produce gastro-intestinal lesions. In the present study we found that aspirin, indomethacin and phenylbutazone caused gastric mucosal damage in 90.9%, 100%, respectively while ibuprofen and paracetamol caused gastric mucosal damage in 33.3% and 37.5% respectively. Thus latter two drugs were safer NSAID's. Further more we have demonstrated that endoscopic monitoring of the patients on NSAID's is a sensitive method of early detection of gastric mucosal damage. This monitoring may be particularly valuable in high risk subjects on NSAID's.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged
/
Female
/
Humans
/
Male
/
Oxyphenbutazone
/
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Ibuprofen
/
Indomethacin
/
Adolescent
Type of study:
Screening study
Language:
English
Year:
1990
Type:
Article
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