In vitro activity of ceftriaxone plus tazobactam against members of Enterobacteriaceae.
Article
in English
| IMSEAR
| ID: sea-90173
ABSTRACT
AIMS:
To study the in vitro activity of ceftriaxone alone and in combination with the beta-lactamase inhibitor tazobactam against bacterial isolates belonging to the Family Enterobacteriaceae.METHODS:
One hundred and five consecutive isolates of Escherichia coli and Klebsiella spp. that had been recovered from various high-risk areas of the hospital were included in the study. MIC estimation to ceftriaxone and a combination of ceftriaxone and tazobactam was performed by the agar dilution method.RESULTS:
By the MIC studies, 88.6% of the strains appeared to be resistant to ceftriaxone with the MIC90 value being > 256 microg/ml. When the MIC were done to ceftriaxone in combination with tazobactam, the resistance rate dropped to 4.8% with the MIC90 value being 4.0 microg/ml.CONCLUSION:
The combination of ceftriaxone and tazobactam appears to be an excellent therapeutic alternative with 94.6% of ceftriaxone resistant strains being susceptible in vitro to this combination.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Beta-Lactamases
/
Ceftriaxone
/
Microbial Sensitivity Tests
/
Cephalosporins
/
Penicillanic Acid
/
Drug Therapy, Combination
/
Enterobacteriaceae
/
Enzyme Inhibitors
/
Hospital Units
/
Anti-Bacterial Agents
Language:
English
Year:
2005
Type:
Article
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