Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.
Article
in English
| IMSEAR
| ID: sea-91182
ABSTRACT
AIM:
To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.METHOD:
A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy.RESULTS:
Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients.CONCLUSION:
The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tamoxifen
/
Triglycerides
/
Breast Neoplasms
/
Aged
/
Female
/
Humans
/
Cholesterol, VLDL
/
Adult
/
Selective Estrogen Receptor Modulators
/
Cholesterol, HDL
Language:
English
Year:
2006
Type:
Article
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