Etiopathophysiology of disseminated intravascular coagulation.
Article
in English
| IMSEAR
| ID: sea-91874
ABSTRACT
Disseminated intravascular coagulation (DIC) involves activation of clotting as well as fibrinolytic pathways. Thrombosis from thrombin release results in end-organ damage, whereas consumption of coagulation factors results in bleeding. Sepsis is the commonest cause of DIC. The consumption of antithrombin in sepsis abrogates its anti-inflammatory role and so its low level is a poor prognostic marker in sepsis. The increased release of plasminogen activator inhibitor-1 (PAI-1) as seen in sepsis decreases fibrinolysis and promotes increased microvascular thrombosis. Here, we discuss the role of inhibitors of coagulation, cytokines, kinins, complement and vasoactive peptides in DIC.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vascular Diseases
/
Wounds and Injuries
/
Blood Coagulation
/
Female
/
Humans
/
Risk Factors
/
Cytokines
/
Disseminated Intravascular Coagulation
/
Fibrinolysis
/
Genital Diseases, Female
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2003
Type:
Article
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