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A multicentric study with arteether in patients of uncomplicated falciparum malaria.
Asthana, O P; Srivastava, J S; Kamboj, V P; Valecha, N; Sharma, V P; Gupta, S; Pande, T K; Vishwanathan, K A; Mahapatra, K M; Nayak, N C; Mahapatra, P K; Mahanta, J; Srivastava, V K; Vasdev,; Singh, N; Shukla, M M; Balsara, A B; Mishra, S K; Satpathy, S K; Mohanty, S; Dash, B.
Article in English | IMSEAR | ID: sea-91883
ABSTRACT
Two hundred and sixty seven patients of uncomplicated P. falciparum malaria completed study in a multicentric phase III clinical trial of Arteether. Arteether was given intramuscularly in a dose of 150 mg daily for three consecutive days. Each patient was followed upto 28 days of alpha, beta arteether therapy. The cure rate was 97% with fever clearance time between 1-7 days (24-168 hours) and parasite clearance time between 1-3 days (24-72 hours). Parasite reappearance rate was found to be 3% and reported at only three of the centres. Following the treatment no adverse effect was observed on haematological, biochemical and vital clinical parameters.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Sesquiterpenes / Aged / Female / Humans / Male / Adolescent / Malaria, Falciparum / Adult / Artemisinins / Middle Aged Type of study: Controlled clinical trial Language: English Year: 2001 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Sesquiterpenes / Aged / Female / Humans / Male / Adolescent / Malaria, Falciparum / Adult / Artemisinins / Middle Aged Type of study: Controlled clinical trial Language: English Year: 2001 Type: Article