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Sickle haemoglobin, G-6PD deficiency and malaria in western Orissa.
Article in English | IMSEAR | ID: sea-92805
ABSTRACT
Sixty cases of malaria were screened for sickle haemoglobin and G-6PD deficiency. Plasmodium vivax was detected in 40 (66%) and Plasmodium falciparum in 21 (35%) cases, with six of the latter having cerebral manifestation. Sickle Hb was found in 7 (11.5%) patients and G-6PD deficiency in 3 (5%) cases. Both patients with SS disease had vivax malaria, while of 5 with sickle cell trait 3 had only vivax, one only falciparum and one mixed infection. Amongst G-6PD deficient patients one had vivax and two falciparum malaria. One of the latter had both SC trait and G-6PD deficiency. Thus, adult persons with SS disease or SC trait were not found to be resistant to either vivax or falciparum malaria. A high frequency (5%) of G-6PD deficiency amongst malaria patients warrants a caution against indiscriminate use of 8-aminoquinoline drugs.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plasmodium falciparum / Plasmodium vivax / Sickle Cell Trait / Humans / Glycogen Storage Disease Type I / Child / Adolescent / Adult / India / Infant Country/Region as subject: Asia Language: English Year: 1990 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plasmodium falciparum / Plasmodium vivax / Sickle Cell Trait / Humans / Glycogen Storage Disease Type I / Child / Adolescent / Adult / India / Infant Country/Region as subject: Asia Language: English Year: 1990 Type: Article