Spontaneously developing autoantibody to factor VIII in an elderly woman: diagnostic and therapeutic challenges.
Article
in English
| IMSEAR
| ID: sea-93065
ABSTRACT
An elderly woman with a continuously bleeding small wound was investigated for the presence of antibodies to FVIII using activated partial time-based screening and confirmatory tests. A late acting coagulation factor inhibitor was detected. The same was characterised to be a low titre antibody against FVIII (5.2 Bethesda units). Cryoprecipitate infusions, corticosteroids and topical desmopressin were unsuccessful in controlling the bleeding. Addition of cyclophosphamide brought about stoppage of bleeding and disappearance of the autoantibody.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Partial Thromboplastin Time
/
Autoantibodies
/
Aged
/
Female
/
Humans
/
Factor VIII
/
Fibrinogen
/
Hemorrhage
Type of study:
Diagnostic study
Language:
English
Year:
2004
Type:
Article
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