A study of plasma alpha-2-macroglobulin levels in type 2 diabetic subjects with microalbuminuria.
Article
in English
| IMSEAR
| ID: sea-93601
ABSTRACT
BACKGROUND:
Alpha-2 macroglobulin (Alpha-2-M) is a major plasma protease inhibitor that also regulates the activity of a variety of bioactive peptides including interleukins and exerts a range of immunomodulatory effects.OBJECTIVE:
We conducted the present study with the objective to study the alpha-2-M levels in type 2 diabetic subjects with microalbuminuria in an attempt to establish alpha-2-M as a predictor of microvascular complications in diabetes. MATERIAL ANDMETHODS:
Plasma Alpha-2-M levels were assayed in 100 (53 males and 47 females) randomly selected type 2 diabetic subjects with microalbuminuria. Diabetes was diagnosed according to the expert committee report of 1998. Patients with any acute metabolic complication like hypoglycemia, ketoacidosis, cerebrovascular accident or any acute infection were not included in the study group.RESULTS:
Majority of patients belonged to 40-60 years age group. In our study alpha-2-M levels indicated a clear increase in diabetic subjects with the increasing age of subjects confirmed by multiple logistical analysis. Alpha-2-M levels were not found to be significantly different between males and females (55.6 +/- 11.3 vs. 53.7 +/- 10.5). Duration of diabetes was found to be an important confounding variable showing a direct positive correlation with alpha-2-M levels and also a significant correlation was found between alpha-2-M levels with different levels of microalbuminuria on multiple logistical analysis. No significant relation of alpha-2-M levels with either fasting blood sugar or HbA1 was observed.CONCLUSION:
The increase in plasma alpha-2 macroglobulin levels in diabetes may be a correlative measure to encounter the potential proteolytic challenge associated with diabetic microangiopathy, even very early in the course of the disease. Alph-2 macroglobulin may yet be one of the most specific markers of microvascular complications in diabetes than any other serum protein.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Severity of Illness Index
/
Aged
/
Female
/
Humans
/
Male
/
Alpha-Macroglobulins
/
Logistic Models
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Probability
/
Predictive Value of Tests
Type of study:
Controlled clinical trial
/
Diagnostic study
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Observational study
/
Prognostic study
/
Risk factors
Language:
English
Year:
2001
Type:
Article
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