Clinical and etiological profile of hyperprolactinemia--data from a tertiary care centre.
Article
in English
| IMSEAR
| ID: sea-93834
ABSTRACT
OBJECTIVE:
To study the clinical presentation and etiology of hyperprolactinemia, a common disorder encountered in endocrine practice.METHODS:
We analyzed the clinical data, hormone profile and imaging reports of 187 females with documented hyperprolactinemia, over a period of 6 years (5 years retrospective analysis and one year prospective study).RESULTS:
Majority of the 187 subjects studied presented in 3rd or 4th decade. Galactorrhoea was the commonest presenting symptom occurring in 159 subjects (85%), followed by amenorrhea in 68.9%; both amenorrhea and galactorrhea were seen in 45.4%. A microprolactinoma was demonstrated in 67 patients (35.8%), a nonfunctioning pituitary macroadenoma with stalk hyperprolactinemia occurred in 30 patients (16%) and polycystic ovarian disease was documented in 24 (12.8%). In 52 patients (27.8%) no apparent cause could be ascertained.CONCLUSIONS:
Syndrome of amenorrhea and/or galactorrhea is the commonest presentation in hyperprolactinemia. Microprolactinoma was the most frequent identifiable etiology followed by idiopathic and stalk hyperprolactinemia in our series.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Hyperprolactinemia
/
Female
/
Humans
/
Prospective Studies
/
Retrospective Studies
/
Age of Onset
/
Adult
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Academic Medical Centers
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Galactorrhea
/
Infertility, Female
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Language:
English
Year:
2005
Type:
Article
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