Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent.
Article
in English
| IMSEAR
| ID: sea-94001
ABSTRACT
OBJECTIVES:
To evaluate the role of Gabapentin in the management of Pentazocine dependence for suppressing muscle aching and craving during its withdrawal. MATERIAL ANDMETHODS:
Patients of Pentazocine dependence were divided in two groups GpA and GpB (n = 10 in each) and were administered Clonidine (P.O.) in first seven days (acute detoxification phase) and later Naltrexone (P.O.) from seventh day onwards (stabilisation-maintenance phase). Gabapentin (1200 mg/day) was additionally added in group B. Muscle pain and craving were rated on 100 mm visual-analogue scale. Psychological dependence was assessed on four step categorical scale.RESULTS:
Group B (Gabapentin group) scored significantly lower (p < 0.001) than group A on both the parameters. Psychological dependence was significantly low (p < 0.01) in Gabapentin group.CONCLUSION:
Gabapentin is an important adjuvant to the management of opiate dependence both in acute detoxification as well as stabilisation phase.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Pentazocine
/
Substance Withdrawal Syndrome
/
Anti-Anxiety Agents
/
Female
/
Humans
/
Male
/
Clonidine
/
Substance-Related Disorders
/
Cyclohexanecarboxylic Acids
Type of study:
Controlled clinical trial
Language:
English
Year:
2003
Type:
Article
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