Effects of commonly used non steroidal anti-inflammatory drugs on gastric mucosa. A clinical, endoscopic and histopathological study.
Article
in English
| IMSEAR
| ID: sea-94584
ABSTRACT
Non steroidal anti-inflammatory drugs (NSAIDS) are known to produce gastro-intestinal lesions. In the present work we found that aspirin, indomethacin and oxyphenbutazone caused gastric mucosal damage in 90.9%, 100% and 100% respectively, while ibuprofen and paracetamol caused damage in 33.3% and 37.5% of cases respectively. Thus the latter two drugs were much safer NSAIDs. Furthermore we demonstrated that endoscopic monitoring of patients on NSAIDs is a sensitive method for early detection of gastric mucosal damage. This monitoring may be particularly valuable in high risk subjects on NSAIDs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aged, 80 and over
/
Aged
/
Female
/
Humans
/
Male
/
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Adolescent
/
Gastroscopy
/
Adult
Type of study:
Screening study
Limits:
Aged80
Language:
English
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS