Some unusual and severe forms of adverse drug reactions: a call for setting adverse drug reaction monitoring centres.
Article
in English
| IMSEAR
| ID: sea-94899
ABSTRACT
Thirty four patients aged 14 to 65 years (18 males and 16 females) admitted to the University Hospital with various unusual and severe forms of adverse drug reactions were studied. It comprised of toxic epidermal necrolysis in 8 patients, systemic vasculitis in 7 of which 3 patients had gangrene of fingers and/or toes, severe erosive gastritis in 9 patients, Stevens-Johnson syndrome in 7 patients, thrombocytopenic purpura in 2 patients and generalised convulsions in 1 patient. Various drugs responsible for causing these adverse drug reactions included antibacterials, antimalarials, anticonvulsants, antituberculars and nonsteroidal anti-inflammatory drugs. Most of the patients recovered. However, 5 of the 8 patients having toxic epidermal necrolysis died of which 2 patients had developed tetanus as a preterminal event. In view of ongoing addition of newer drugs to the therapeutic armamentarium and an increasing incidence of various unusual and severe forms of adverse drug reactions, it is our contention that a separate adverse drug reaction monitoring cell should be established in every hospital setting.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vasculitis
/
Aged
/
Female
/
Humans
/
Male
/
Retrospective Studies
/
Adolescent
/
Stevens-Johnson Syndrome
/
Drug Monitoring
/
Adult
Type of study:
Observational study
Country/Region as subject:
Asia
Language:
English
Year:
1998
Type:
Article
Similar
MEDLINE
...
LILACS
LIS