Antibody to hepatitis-C virus in multi-transfused thalassaemics--Indian experience.
Article
in English
| IMSEAR
| ID: sea-94993
ABSTRACT
Twelve out of 72 (16.7%) multi-transfused patients with thalassemia major (age range 7-22 years) were found to be positive for antibody to hepatitis-C virus (anti-HCV). Nine (75%) of these 12 cases were positive for hepatitis B core antibody (anti-HBc) and/or hepatitis B surface antibody (anti-HBs). Out of the remaining 60 patients (83.3%), 27 patients (45%) were positive for anti-HBc and/or anti-HBs, while six (10%) were HBsAg positive Anti-HCV positive patients had significant higher levels of liver enzymes than those who were negative (p < 0.01). S. Ferritin was also significantly higher in those with seropositivity for anti-HCV than those who were negative (p < 0.01). It is concluded that HCV (besides HBV) is a major problem in multi-transfused thalassemia major patients and routine pre-transfusion screening of blood for anti-HCV must be introduced in the blood banks.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Blood Transfusion
/
Female
/
Humans
/
Male
/
Child
/
Hepatitis B virus
/
Adolescent
/
Beta-Thalassemia
/
Hepacivirus
/
Adult
Country/Region as subject:
Asia
Language:
English
Year:
1993
Type:
Article
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