Effect of gugulipid on bioavailability of diltiazem and propranolol.
Article
in English
| IMSEAR
| ID: sea-95588
ABSTRACT
The effect of single oral dose of 1 gm gugulipid was studied on bioavailability of single oral dose of propranolol (40 mg) and diltiazem (60 mg) in 10 and 7 normal healthy male volunteers respectively. It was a randomised within group crossover study. Blood samples were collected at hourly intervals upto 8 hrs. Gugulipid significantly reduced (P < .01) peak plasma concentration (Cmax) and area under curve (AUC 0-8 hrs) of both the drugs in normal volunteers. Such interaction in patients receiving propanolol or diltiazem with gugulipid may lead to diminished efficacy or nonresponsiveness due to significant reduction in bioavailability.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Propranolol
/
Humans
/
Male
/
Plant Extracts
/
Diltiazem
/
Biological Availability
/
Administration, Oral
/
Cross-Over Studies
/
Adult
/
Commiphora
Type of study:
Controlled clinical trial
Language:
English
Year:
1994
Type:
Article
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