Familial childhood systemic lupus erythematosus: report of 2 cases.
J Indian Med Assoc
;
2007 Mar; 105(3): 141, 148
Article
in English
| IMSEAR
| ID: sea-96613
ABSTRACT
Systemic lupus erythematosus is a multisystem organ inflammation due to damage of cells and tissues by pathogenic auto-antibodies and immune complexes. The most important factor for the causation of familial systemic lupus erythematosus is genetic on which environmental factor usually coexists. Two brothers of 7 and 3 years of age having childhood systemic lupus erythematosus are reported here because of low incidence and familial occurrence. Both the children fulfilled the American Rheumatology Association (ARA) criterion of systemic lupus erythematosus though anti-dsDNA was negative in both and antinuclear factor was positive only in the younger child. Systemic lupus erythematosus begins in childhood in 20% of adult patients and usually after the age of 8 years but here onset was even at an earlier age. The treatment of the both the siblings included administration of steroids and cyclophosphamide.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Male
/
Drug Administration Schedule
/
Prednisolone
/
Child
/
Child, Preschool
/
Cyclophosphamide
/
Siblings
/
Immunosuppressive Agents
/
Lupus Erythematosus, Systemic
Language:
English
Journal:
J Indian Med Assoc
Year:
2007
Type:
Article
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