Toxicity and side-effects of combination chemohormonal therapy of advanced breast cancer.
J Indian Med Assoc
;
1992 Feb; 90(2): 39-42
Article
in English
| IMSEAR
| ID: sea-97345
ABSTRACT
Seventy-five female patients suffering from advanced breast cancer were treated with toilet mastectomy, radiotherapy and oophorectomy (if premenopausal) or tamoxifen therapy (if postmenopausal) as well as chemotherapy with cyclophosphamide, methotrexate, 5-fluorouracil and prednisone. The most common side-effects of combined chemohormonal therapy were gastro-intestinal (nausea, vomiting, rarely diarrhoea) in 43 patients (57.3%), followed by alopecia in 23 patients (30.6%), myelosuppression in 12 patients (16%), extravasation and thrombophlebitis in 7 patients (9.3%), and mucositis and oral erythema in 3 patients (4%). Side-effects of tamoxifen therapy such as vaginal discharge, bleeding, hot flushes were encountered in 10 patients (13.3%). Hypercalcaemia, tumour flare and hepatic, renal, cardiac, pulmonary and neurological toxicities were not encountered. Improvement of 10-30% in Karnofsky performance status was noted in responders while 20-30% deterioration was observed in non-responders. Combination therapy was mostly well tolerated, side-effects were few and toxicities were temporary and reversible.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tamoxifen
/
Thrombophlebitis
/
Vomiting
/
Breast Neoplasms
/
Female
/
Humans
/
Prednisone
/
Ovariectomy
/
Antineoplastic Combined Chemotherapy Protocols
/
Methotrexate
Language:
English
Journal:
J Indian Med Assoc
Year:
1992
Type:
Article
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