A study of Vitamin K status in children on prolonged antibiotic therapy.
Indian Pediatr
;
2003 Jan; 40(1): 36-40
Article
in English
| IMSEAR
| ID: sea-9804
ABSTRACT
Vitamin K deficiency is known to cause coagulopathy and bleeding in patients on prolonged antibiotic therapy. This study was conducted to evaluate the status of vitamin K deficiency in hospitalized children on prolonged antibiotic therapy and its role in reversing the coagulopathy. A prospective non-randomized study was conducted on children on antibiotic therapy at a tertiary care hospital. Children in the 1 month-1 year age group developed significant coagulopathy as compared to other age groups. Coagulation abnormalities were also seen to be more in children with greater grades of malnutrition, on a more prolonged course of antibiotics and in children who were critically ill in intensive care. Hypoprothrombinemia previously reported to be due to B-lactam antibiotics containing the N-Methyl Thio Tetrazole (NMTT) group also resulted from antibiotics without this side chain. Inhibition of intestinal microorganisms by antibiotics was thought to be a likely explanation of this phenomenon. We suggest Vitamin K prophylaxis in severely ill patients, on extended periods of antibiotics and inadequate diet to prevent morbidity and mortality.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Vitamin K
/
Vitamin K Deficiency
/
Humans
/
Child
/
Child, Preschool
/
Prospective Studies
/
Treatment Outcome
/
Hospitalization
/
Hypoprothrombinemias
/
Infant
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Journal:
Indian Pediatr
Year:
2003
Type:
Article
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