Growth pattern and final height in 21-hydroxylase deficiency.
Indian Pediatr
;
2007 Oct; 44(10): 771-3
Article
in English
| IMSEAR
| ID: sea-9974
ABSTRACT
Growth pattern and final height were evaluated in 47 children with 21-hydroxylase deficiency to identify factors influencing growth. The subjects were followed-up from the age of 0.6 +/- 1.2 years for 8.8 +/- 3.9 years. Final height SDS was significantly below target height SDS (- 2.5 +/- 1.4 versus - 1.0 +/- 1.0, P < 0.001). Laboratory monitoring and type of disease (salt-wasting or simple virilizing) significantly influenced age-specific height SDS. Age at treatment, frequency of laboratory monitoring and dose of glucocorticoid during infancy influenced final height on univariate analysis; the effect was not sustained on multivariate analysis. Our study emphasizes the need for regular laboratory monitoring and lower glucocorticoid dose during infancy in 21-hydroxylase deficiency.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Body Height
/
Female
/
Humans
/
Male
/
Child
/
Child Development
/
Retrospective Studies
/
Follow-Up Studies
/
Adolescent
/
Adrenal Hyperplasia, Congenital
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Indian Pediatr
Year:
2007
Type:
Article
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