Clinical Efficacy of AST/ALT Ratio and Platelet Counts as Predictors of Degree of Fibrosis in HBV Infected Patients without Clinically Evident Liver Cirrhosis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 246-251, 2004.
Article
in Korean
| WPRIM
| ID: wpr-100002
ABSTRACT
BACKGROUND/AIMS:
Hepatic fibrosis is an important prognostic factor in chronic hepatitis B. Liver biopsy is a gold standard diagnostic tool but an invasive procedure, so it cannot be done on all patients. We evaluated the clinical efficacy of AST/ALT ratio and platelet counts as predictors of fibrosis in chronic hepatitis B.METHODS:
We reviewed retrospectively clinical records of 323 patients, who visited Kyungpook National University Hospital for chronic hepatitis B and underwent liver biopsy from September 1998 to May 2002. Correlation with laboratory parameters with hepatic fibrosis stage was identified.RESULTS:
Of 323 patients, there were 278 male patients with mean age 27 (9~59). Platelet counts showed a significant correlation (r=-0.343, p=0.000), and AST/ALT ratio showed a weak but significant correlation (r=0.137, p=0.013) with fibrosis stage. Patients with severe fibrosis or cirrhosis (stage 3 and 4) can be identified to have AST/ALT ratio > 1 and platelet counts 1 in combination with platelet counts. However, its sensitivity is too low to replace liver biopsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Aspartate Aminotransferases
/
English Abstract
/
Biomarkers
/
Predictive Value of Tests
/
Sensitivity and Specificity
/
Hepatitis B, Chronic
/
Alanine Transaminase
/
Liver
/
Liver Cirrhosis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS