Analysis of the Effectiveness of Blotting Assays for Donor Blood Screening / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 1-8, 2011.
Article
in Korean
| WPRIM
| ID: wpr-100052
ABSTRACT
BACKGROUND:
Immunoblot assays (IBAs) have been widely used to confirm the reactivity of immunoassay. However, indeterminate (ID) results have shown the limits for interpreting IBAs. There is some debate about the benefit of these assays. We assessed the actual status of the IBAs for the donor screening process and we proposed more available algorithms.METHODS:
We analyzed the data from the blood information management system of the Korean Red Cross. This study was approved by the Institutional Review Board of the KRC. The analyzed data included the present condition of various utilities and the results of the IBAs in the world.RESULTS:
The infectivity of the ID results in IBAs seemed not to be high, but the safety could not be assured. IBA for HTLV was used as a confirmatory test in many countries. Most of the eligible blood donors could be saved by IBAs.CONCLUSION:
IBAs seem to be valuable methods as supplemental and follow up tests for ID results. Furthermore, IBAs were useful to distinguish eligible blood donors. When donors show positive results on an immunoassay and NAT (HIV and HCV) concurrently, then IBA does not seem to be required. Only a RIBA for HCV is recommended for the donors showing a S/CO ratio above 2.0 on immunoassay. The additional alternative immunoassay would be effective in the HTLV screening algorithm.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Red Cross
/
Tissue Donors
/
Uronic Acids
/
Blood Donors
/
Immunoassay
/
Mass Screening
/
Follow-Up Studies
/
Information Management
/
Ethics Committees, Research
/
Donor Selection
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2011
Type:
Article
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