The Evaluation of Topical Anesthetic Effects of a Liposome Encapsulated Mixture of Local Anesthetics (Lipo-MLA) / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 420-426, 2001.
Article
in Korean
| WPRIM
| ID: wpr-100263
ABSTRACT
BACKGROUND:
This study investigated the effect of topical analgesic effects of a liposome encapsulated mixture of local anesthetics (lipo-MLA) compared with EMLA.METHODS:
3% lipo-MLA (0.5% tetracaine base, 2.5% lidocaine base) and 5% lipo-MLA (1% tetracaine base, 4% lidocaine base) were encapsulated into liposomal vesicles made with egg yolk phosphatidylcholine, cholesterol and phosphatidyldioleoyl. 3% lipo-MLA and EMLA were applied to volunteers' forearms bilaterally with and without an occlusive dressing. The topical anesthetic effects of the lipo-MLA and EMLA as a control were evaluated by the pinprick test in 28 adult volunteers after 60 minutes of application. The analgesic influence of the concentration of local anesthetics was also compared with 3% and 5% lipo-MLA under a non-occlusive dressing.RESULTS:
Analgesic effects of the 3% lipo-MLA were similar with EMLA under an occlusive dressing for 60 minutes. In addition, analgesic effects of the 3% lipo-MLA under a non-occlusive dressing were more potent than EMLA. Lipo-MLA under a non-occlusive dressing showed more potent analgesic effect than lipo-MLA under an occlusive dressing. 5% lipo-MLA was more potent than 3% lipo-MLA under a non-occlusive dressing.CONCLUSIONS:
Lipo-MLA has more potent analgesic effects than EMLA without an occlusive dressing and 5% lipo-MLA is more potent than 3% lipo-MLA. Therefore, lipo-MLA appeared to be an improved topical analgesic formulation which provides a more potent and convenient topical application.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphatidylcholines
/
Tetracaine
/
Bandages
/
Volunteers
/
Cholesterol
/
Egg Yolk
/
Forearm
/
Anesthetics
/
Anesthetics, Local
/
Lidocaine
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2001
Type:
Article
Similar
MEDLINE
...
LILACS
LIS