Evaluation of Marsh's Pharmacokinetic Parameter Set for Target Controlled Infusion of Propofol in Korean / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 282-292, 2001.
Article
in Korean
| WPRIM
| ID: wpr-100281
ABSTRACT
BACKGROUND:
Marsh's pharmacokinetic parameter set is the most widely used parameter for target controlled infusion for propofol. However, Marsh's model was derived from a European population, and it is uncertain whether this model is accurate for Koreans.METHODS:
Thirty ASA 1 or 2 adult patients undergoing orthopedic surgery participated in this study. Atropine 0.5 mg was injected for premedication. Anesthesia was induced by a TCI of propofol with a target concentration of 6 microgram/ml and maintained around 3 - 5 microgram/ml according to the bispectral index (35 - 45). In the middle of surgery, target concentrations were increased to 6 microgram/ml and maintained until effect site concentration was the same concentration. Three minutes after equilibration, 3 ml of blood was drawn from the radial artery and contralateral antecubital cephalic vein for measuring blood concentration using HPLC. Target concentrations were gradually decreased at the interval of 1 microgram/ml until the end of surgery and a blood sample was drawn as described in the method. A sample for every 1 microgram/ml was collected in the recovery room. Performance error of the predicted concentration of blood was calculated.RESULTS:
The performance error was -12.86 - 16.55% for 1 - 6 microgram/ml of predicted concentration. Measured concentrations were higher than predicted at higher concentrations, but lower at lower concentrations. Measured cardiac output and arteriovenous concentration differences at 1 - 6 microgram/ml showed no difference.CONCLUSIONS:
Marsh's pharmacokinetic model was accurate for propofol TCI in Koreans in terms of relatively low performance error (< 20%) in the concentration range of 1 - 6 microgram/ml.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orthopedics
/
Premedication
/
Recovery Room
/
Atropine
/
Veins
/
Cardiac Output
/
Propofol
/
Chromatography, High Pressure Liquid
/
Radial Artery
/
Anesthesia
Type of study:
Prognostic study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2001
Type:
Article
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