Experimental Model of Cardiac Xenograft , Mouse Heart to Rat / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 1-4, 1999.
Article
in Korean
| WPRIM
| ID: wpr-100295
ABSTRACT
BACKGROUND:
The transplantation of organs between phylogenetically disparate or harmonious species has invariably failed due to the occurrence of hyperacute rejection or accerelated acute rejection. But concordant cardiac xenograft offer us an opportunity to study xenotransplantation in the absence of hyperacute rejection. Current therapeutics for the prolongation of survival of rodent concordant xenotransplantation are not ideal with many regimens having a high mortality rate. Cyclosporine A & Mycophenolate Mofetil are new immunosuppresive agent which has been shown to be effective at prolonging survival of allograft, as purine synthesis inhibitor. MATERIAL ANDMETHOD:
We used white mongrel rats as recipient and mice as donor, divided 4 groups(n=6), control group(Group 1) has no medication or pretreatment, Group 2 has splenectomy as pretreatment 7~10 days before transplantation, Group 3 has Cyclosporine A treatment group, Group 4 has combined treatment of Cyclosporine A & Mycophenolate Mofetil(RS 61443). We compared survival time.RESULT:
We can't find significant difference of survival time between each groups.CONCLUSION:
We concluded that rejection of cardiac xenograft was different from rejection of allograft, and new immunossuppresive Agent(Mycophenolate Mofetil, Cyclosporine A) was not effective for prolongation of survival time after cardiac xenograft.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rodentia
/
Splenectomy
/
Tissue Donors
/
Transplantation
/
Transplantation, Heterologous
/
Mortality
/
Immunosuppression Therapy
/
Cyclosporine
/
Allografts
/
Heterografts
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
1999
Type:
Article
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