Expression of Angiopoietin-1 and Angiopoietin-2 mRNA in Eutopic and Ectopic Endometrium / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1171-1178, 2004.
Article
in Korean
| WPRIM
| ID: wpr-100308
ABSTRACT
OBJECTIVE:
To investigate the mRNA expression of Angiopoietin (Ang)-1 and Ang-2 in ectopic and eutopic endometrium from women with or without endometriosis throughout the menstrual cycle.METHODS:
Total RNA was extracted and reverse transcribed into cDNA. The expression of Ang-1 and Ang-2 was examined by quantative competitive PCR (QC PCR) and each result was analyzed by Kruskal- Wallis analysis and Mann-Whitney U-test.RESULTS:
The expression of Ang-1 mRNA was statistically significantly higher in endometrium of follicular phase from women with endometriosis compared to that from normal ones in the follicular phase. Endometriotic tissues expressed significantly lower Ang-2 mRNA compared to endometrium from women without endometriosis.CONCLUSION:
We suggested that the expression of Ang-1 mRNA could be associated with the pathogenesis of endometriosis and might have a role as neovascularizaton and survival of ectopic endometrium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA
/
RNA, Messenger
/
Polymerase Chain Reaction
/
DNA, Complementary
/
Angiopoietin-1
/
Angiopoietin-2
/
Endometriosis
/
Endometrium
/
Follicular Phase
/
Menstrual Cycle
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2004
Type:
Article
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