Incidence of adverse reactions to whole blood donation in China: a Meta-analysis / 中国输血杂志

ABSTRACT

【Objective】 To systematically evaluate the characteristics of adverse reactions to blood donation(ARBD) among whole blood donors in China, so as to provide scientific basis for the prevention and control of adverse reactions related to blood donation. 【Methods】 PubMed, EMbase, CNKI, VIP and WanFang Data were retrieved to collect research literature concerning ARBD among whole blood donors in mainland China with observation time≥6 months. The retrieval time was set from the time of database establishment to June 2020. The literature was supplemented by reference tracing and manual retrieval. Two reviewers independently screened the literature, extracted the data, and evaluated the methodological quality of the included studies according to the inclusion and exclusion criteria. Then Review Manager 5.3 software was used for Meta analysis. 【Results】 A total of 36 literature were included, involving 3 769 415 blood donors and 38 403 cases of ARBD. Meta-analysis results showed that the overall incidence of ARBD among whole blood donors was 1.36% [95%CI (1.19, 1.54)], and 1.52% [(95%CI (1.26, 1.78)] in the eastern, 1.26% [(95%CI (0.87, 1.70)] in the central, and 0.76% [(95%CI (0.74, 1.21)] in the western China when stratifying by geographic distribution, with statistically significant differences (P<0.01). The incidence of ARBD in male and female whole blood donors was 1.19% [(95%CI (0.99, 1.39)] and 1.26% [(95%CI (1.05, 1.48)), respectively, which was more commonly reported by women than by men (P<0.01). The incidence of ARBD was 2.17% [(95%CI (1.82, 2.52)], 0.98% [(95%CI (0.82, 1.14)] and 0.76% [(95%CI (0.61, 0.91)] in the age groups of 18~24, 25~40, and 41~55, respectively, and the incidence in donors aged 18~24 years was significantly higher than that in other two age ranges (P<0.01). The incidence of ARBD in first-time and repeat blood donors was 1.57% [(95%CI (1.35, 1.79)] and 0.63% [(95%CI (0.56, 0.70)), respectively(P<0.01). The incidence of ARBD with blood donation <400 mL and 400 mL was 1.10% [(95%CI (0.90, 1.30), P<0.001] and 0.87% [(95%CI (0.71, 1.03), P<0.001], respectively(P<0.01). 【Conclusion】 In order to improve the effectiveness of ARBD monitoring, it is necessary to unify the standards for ARBD, strengthen the knowledge training of ARBD, and accelerate the information construction to explore the national ARBD monitoring mode.