Fulminant Epstein-Barr Virus-associated T-cell Lymphoproliferative Disorder in an Immunocompetent Middle-aged Man Presenting with Chronic Diarrhea and Gastrointestinal Bleeding
Journal of Korean Medical Science
;
: 1103-1107, 2011.
Article
in English
| WPRIM
| ID: wpr-100568
ABSTRACT
The World Health Organization (WHO) recently defined systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPD) of childhood as a life-threatening illness. However, this rare disease has not been extensively studied. Here we report a case of systemic EBV-positive T-cell LPD in a previously healthy middle-aged man with a chief complaint of chronic diarrhea. The initial colon biopsy showed focal infiltration of EBV-positive small lymphocytes without any atypia. However, the disease rapidly progressed and the patient required a total colectomy due to severe gastrointestinal bleeding. Three and half months after admission, the patient died from a complication of disseminated intravascular coagulation. The resected colon showed diffuse infiltration of EBV-positive atypical lymphocytes with ischemic change. Most atypical lymphocytes were CD3+ or CD5+. The monoclonality of EBV was demonstrated by sequence variation analysis of the latent membrane protein 1 (LMP1) gene in the colectomy specimen as well as in the initial biopsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Viral
/
T-Lymphocytes
/
Chronic Disease
/
Colonoscopy
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Infections
/
Diarrhea
/
Disseminated Intravascular Coagulation
/
Feces
/
Gastrointestinal Hemorrhage
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS