Your browser doesn't support javascript.
loading
Efficacy of oral lycopene supplementation for photoprotection in Filipino patients in a Tertiary Hospital in Makati: A single-blind randomized controlled trial
Journal of the Philippine Dermatological Society ; : 96-102, 2023.
Article in English | WPRIM | ID: wpr-1006535
ABSTRACT
Background@#Ultraviolet radiation has been proven to result in unwarranted effects on the skin through reactive oxygen species (ROS) and direct DNA damage. Lycopene, a naturally occurring substance, acts as an antioxidant by neutralizing ROS.@*Objective@#The objective of the study was to determine the efficacy of oral lycopene supplementation for photoprotection in adult Filipino patients seen in a tertiary hospital in Makati City.@*Design@#The study design involves single-blind, parallel, randomized controlled trial.@*Methods@#Thirty-six Filipino patients aged 18 years old and above with Fitzpatrick Skin Phototype (FSP) III–V were divided into two groups using a computer-generated randomization. Group A received lycopene 500 mg/ soft gel capsule two capsules per orem once daily for 12 weeks, while Group B received no intervention during the entire observation period. Minimal erythema dose (MED) of patients from both groups was assessed by a single treatment-blinded reader at baseline, week 6, and week 12.@*Results@#Group A showed a significant increase in MED across periods, with a 20.83% increase from baseline at week 6 and a 43.06% increase at week 12. Group B MED remained constant from baseline to week 6 and to week 12. These results show that there is a significant effect in the increase in MED as compared to the control group.@*Conclusion@#Oral lycopene is effective in increasing the MED of patients and may be used for photoprotection among patients with FSP III–V.
Subject(s)

Search on Google
Index: WPRIM (Western Pacific) Main subject: Lycopene Language: English Journal: Journal of the Philippine Dermatological Society Year: 2023 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Search on Google
Index: WPRIM (Western Pacific) Main subject: Lycopene Language: English Journal: Journal of the Philippine Dermatological Society Year: 2023 Type: Article