The Effect of Telmisartan on Endothelial Function and Arterial Stiffness in Patients With Essential Hypertension
Korean Circulation Journal
;
: 180-184, 2009.
Article
in English
| WPRIM
| ID: wpr-100657
ABSTRACT
BACKGROUND AND OBJECTIVES:
Several studies have shown that angiotensin II receptor blockers (ARBs) improve endothelial function and arterial stiffness. Telmisartan is a highly selective ARB that activates peroxisome proliferator-activated receptor gamma (PPARgamma). The purpose of this study was to evaluate the effects of telmisartan, such as endothelial function, arterial stiffness, and insulin sensitivity, in patients with essential hypertension. SUBJECTS ANDMETHODS:
Thirty-nine patients with essential hypertension were administered telmisartan (80 mg once daily) using an open-labeled and prospective protocol. The patients were examined before and 8 weeks after treatment to assess changes in flow mediated-vasodilation (FMD), pulse wave velocity (PWV), quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment (HOMA), and adiponection.RESULTS:
The systolic and diastolic blood pressure (BP) decreased from 153+/-15 mmHg and 90+/-13 mmHg to 137+/-16 mmHg and 84+/-10 mmHg after telmisartan treatment, respectively (p<0.01). Telmisartan therapy increased the FMD from 7.6+/-3.5 to 9.0+/-2.8% (p<0.01). The following parameters of arterial stiffness were significantly improved after telmisartan therapy brachial-ankle pulse wave velocity (baPWV), from 17.2+/-3.1 to 15.9+/-2.6 m/sec; heart-carotid PWV (hcPWV), from 9.7+/-1.8 to 9.0+/-1.9 m/sec; and heart-femoral PWV (hfPWV), from 11.3+/-1.9 to 10.7+/-1.9 m/sec (p<0.01). There were no changes in QUICKI, the HOMA level, and plasma adiponectin (p=NS).CONCLUSION:
These results suggest that telmisartan is effective in improving endothelial function and arterial stiffness in patients with essential hypertension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Arteriosclerosis
/
Benzimidazoles
/
Benzoates
/
Blood Pressure
/
Insulin Resistance
/
Endothelium, Vascular
/
Prospective Studies
/
PPAR gamma
/
Angiotensin II Type 1 Receptor Blockers
Type of study:
Practice guideline
/
Observational study
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2009
Type:
Article
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