Influencing factors of coronary artery lesions in children with Kawasaki disease / 西安交通大学学报(医学版)

ABSTRACT

【Objective】 To study the influencing factors of blood source indicators related to coronary artery lesions in children with Kawasaki disease (KD). 【Methods】 Clinical data of children diagnosed with KD admitted to our hospital from January 1, 2015 to December 31, 2019 were retrospectively analyzed. Baseline data comparison and multivariate Logistic regression analysis were used to compare the differences in blood source indicators between the coronary artery lesion (CAL) group and the non-coronary artery lesion (nCAL) group, and the receiver operating characteristic (ROC) curve was drawn. 【Results】 There were significant differences in sex, erythrocyte sedimentation rate (ESR), lymphocyte count (L#) and red blood cell distribution width (RDW) between the CAL group and the nCAL group (P<0.05). Male, lower ESR, lower L#, and higher RDW were independent risk factors for CAL. OR values and their 95% confidence intervals (95% CI) were 0.279 (0.117, 0.669), 0.973 (0.955, 0.992), 0.675 (0.513, 0.889), and 2.433 (1.313, 4.506), respectively. The sensitivity and specificity of RDW for predicting CAL were 37.3% and 86.4%, the best cutoff value was 13.45%, the area under curve (AUC) was 0.616, and 95% CI was (0.514, 0.718) (P<0.05). ESR and L# had no predictive value for CAL. 【Conclusion】 Blood source indicators of children with Kawasaki disease, including blood routine and inflammatory indicators, especially RDW, have certain predictive value for coronary artery lesions. They can be combined with echocardiography to evaluate disease progression.