Expression and roles of NUPR1 in cholangiocarcinoma cells / 대한해부학회지
Anatomy & Cell Biology
;
: 17-25, 2012.
Article
in English
| WPRIM
| ID: wpr-100677
ABSTRACT
Nuclear protein-1 (NUPR1) is a small nuclear protein that is responsive to various stress stimuli. Although NUPR1 has been associated with cancer development, its expression and roles in cholangiocarcinoma have not yet been described. In the present study, we found that NUPR1 was over-expressed in human cholangiocarcinoma tissues, using immunohistochemistry. The role of NUPR1 in cholangiocarcinoma was examined by its specific siRNA. NUPR1 siRNA decreased proliferation, migration and invasion of human cholangiocarcinoma cell lines (HuCCT1 and SNU1196 cells). From these results, we conclude that NUPR1 is over-expressed in cholangiocarcinoma and regulates the proliferation and motility of cancer cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunohistochemistry
/
Nuclear Proteins
/
Cell Line
/
Cholangiocarcinoma
/
RNA, Small Interfering
Limits:
Humans
Language:
English
Journal:
Anatomy & Cell Biology
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS