Molecular classification of small cell lung cancer subtypes: Characteristics, prognostic factors, and clinical translation / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 130-139, 2024.
Article
in English
| WPRIM
| ID: wpr-1007670
ABSTRACT
Small cell lung cancer (SCLC) is a highly malignant tumor with a very poor prognosis; therefore, more effective treatments are urgently needed for patients afflicted with the disease. In recent years, emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology, metastasis, immune microenvironment, and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC phenotypes. Additionally, advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the disease. Herein, we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Prognosis
/
Genomics
/
Small Cell Lung Carcinoma
/
Tumor Microenvironment
/
Lung Neoplasms
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2024
Type:
Article
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