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Biosynthesis of immunosuppressant tacrolimus: a review / 生物工程学报
Chinese Journal of Biotechnology ; (12): 3095-3110, 2023.
Article in Chinese | WPRIM | ID: wpr-1007947
ABSTRACT
Tacrolimus (FK506) is a 23-membered macrolide with immunosuppressant activity that is widely used clinically for treating the rejection after organ transplantation. The research on tacrolimus production was mainly focused on biosynthesis methods, within which there are still some bottlenecks. This review summarizes the progress made in tacrolimus biosynthesis via modification of metabolic pathways and control of fermentation process, with the hope to address the technical bottlenecks for tacrolimus biosynthesis and improve tacrolimus production by fermentation engineering and metabolic engineering.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tacrolimus / Macrolides / Fermentation / Immunosuppressive Agents / Anti-Bacterial Agents Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2023 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tacrolimus / Macrolides / Fermentation / Immunosuppressive Agents / Anti-Bacterial Agents Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2023 Type: Article