mRNA vaccines for infectious diseases: research progress and applications / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 3966-3984, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-1008006
ABSTRACT
Messenger RNA (mRNA) vaccines emerge as promising vaccines to prevent infectious diseases. Compared with traditional vaccines, mRNA vaccines present numerous advantages, such as high potency, safe administration, rapid production potentials, and cost-effective manufacturing. In 2020, two COVID-19 vaccines (BNT162b2 and mRNA-1273) were approved by the Food and Drug Administration (FDA). The two vaccines showed high efficiency in combating COVID-19, which indicates the great advantages of mRNA technology in developing vaccines against emergent infectious diseases. Here, we summarize the type, immune mechanisms, modification methods of mRNA vaccines, and their applications in preventing infectious diseases. Current challenges and future perspectives in developing mRNA vaccines are also discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
United States
/
RNA, Messenger
/
Communicable Diseases
/
COVID-19 Vaccines
/
MRNA Vaccines
/
BNT162 Vaccine
Limits:
Humans
Country/Region as subject:
North America
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2023
Type:
Article
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