Advances in the biosynthesis of cyclodipeptide type natural products derived from actinomycetes / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 4497-4516, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-1008038
ABSTRACT
Cyclodipeptide (CDP) composed of two amino acids is the simplest cyclic peptide. These two amino acids form a typical diketopiperazine (DKP) ring by linking each other with peptide bonds. This characteristic stable ring skeleton is the foundation of CDP to display extensive and excellent bioactivities, which is beneficial for CDPs' pharmaceutical research and development. The natural CDP products are well isolated from actinomycetes. These bacteria can synthesize DKP backbones with nonribosomal peptide synthetase (NRPS) or cyclodipeptide synthase (CDPS). Moreover, actinomycetes could produce a variety of CDPs through different enzymatic modification. The presence of these abundant and diversified catalysis indicates that actinomycetes are promising microbial resource for exploring CDPs. This review summarized the pathways for DKP backbones biosynthesis and their post-modification mechanism in actinomycetes. The aim of this review was to accelerate the genome mining of CDPs and their isolation, purification and structure identification, and to facilitate revealing the biosynthesis mechanism of novel CDPs as well as their synthetic biology design.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
Biological Products
/
Actinomyces
/
Actinobacteria
/
Diketopiperazines
/
Amino Acids
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2023
Type:
Article
Similar
MEDLINE
...
LILACS
LIS