Ferroptosis:Mechanism and Role in Malignant Tumors / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 647-654, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-1008112
ABSTRACT
Ferroptosis is a new type of programmed cell death different from other cell death pathways such as apoptosis,autophagy,necrosis,and pyroptosis in terms of initiation,mechanisms,and molecular characteristics.As the accumulation of phospholipid hydroperoxides is the hallmark of ferroptosis,the balance between oxidative damage and antioxidant defense is critical to the regulatory mechanism of ferroptosis.In cancer,the upregulation of antioxidant defense pathways can inhibit ferroptosis,thereby promoting cancer cells to survive the oxidative stress and develop drug resistance.This review systematically introduces the main features and regulatory mechanisms of ferroptosis.In addition,we summarize the role of ferroptosis in the progression and drug resistance of malignant tumors,providing novel implications for further research on the pathogenesis of malignant tumors and discovery of new targets for anti-cancer therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Apoptosis
/
Ferroptosis
/
Neoplasms
/
Antioxidants
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2023
Type:
Article
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