Advances in the Role of Low-Dose Interleukin-2 in Immune-Mediated Dermatosis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 683-688, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1008117
Responsible library:
WPRO
ABSTRACT
Immune-mediated dermatoses are the skin diseases caused by the breakdown of immune tolerance,including lupus erythematosus and dermatomyositis.The imbalance between regulatory T cells (Tregs) and effector T cells (Teffs) plays a key role in the pathogenesis of these diseases.Low-dose interleukin-2 can preferentially activate Tregs and reverse the imbalance between Tregs and Teffs to recover the immune tolerance,which has attracted attention in the treatment of immune-mediated dermatoses.This review summarizes the research progress in the immunomodulatory mechanism and clinical application of low-dose interleukin-2 in immune-mediated dermatoses,providing a new idea for the clinical treatment of these diseases.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Skin Diseases
/
Interleukin-2
/
T-Lymphocytes, Regulatory
/
Lupus Erythematosus, Systemic
Limits:
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2023
Type:
Article