Advances in Allogeneic Chimeric Antigen Receptor T Cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 967-972, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-1008154
ABSTRACT
Autologous chimeric antigen receptor(CAR)T-cell therapy has improved the prognosis of hematological malignancies.Nevertheless,allogeneic CAR-T cells have potential advantages over the autologous approach available on the market.However,allogeneic CAR-T cells may cause life-threatening graft-versus-host disease(GVHD)or be rapidly eliminated by the host immune system.In this review,we analyze the different sources of T cells for optimal allogeneic CAR-T cell therapy,describe the different approaches,and introduce the gene editing measures to produce allogeneic CAR-T cells with limited potential for GVHD and improved anti-tumor effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-Lymphocytes
/
Immunotherapy, Adoptive
/
Hematopoietic Stem Cell Transplantation
/
Receptors, Chimeric Antigen
/
Graft vs Host Disease
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2023
Type:
Article
Similar
MEDLINE
...
LILACS
LIS