Synthesis and antitumor activity of podophyllotoxin derivatives / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4874-4879, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-1008176
ABSTRACT
According to drug design flattening principle and using podophyllotoxin or 4'-demethylepipodophyllotoxin and aldehydes as starting material,a series of podophyllotoxin derivatives containing an imine structure with low toxicity were highly effective synthesized. Nine target compounds were successfully synthesized,and their structures were confirmed by ~1H-NMR,HR-ESI-MS and melting point data analysis. Using etoposide as positive control drug,nine target compounds were screened for cytotoxicity against He La cells in vitro by MTT method. The antitumor activity screening results showed that compound 6 b,6 d,6 e,6 f,6 g,6 i exhibited higher inhibitory rate against He La cells than those of control drug VP-16. It provides some practical reference value for the further development on the structure modification of podophyllotoxin and study on anti-tumor activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Podophyllotoxin
/
Structure-Activity Relationship
/
Drug Screening Assays, Antitumor
/
Drug Design
/
Antineoplastic Agents
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2019
Type:
Article
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