A new spirocyclic cycloartane triterpenoid from Souliea vaginata / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4476-4480, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-1008216
ABSTRACT
The 70% ethanol extract of the whole plant of Souliea vaginata was purified by multi-chromatographic methods including macroporous resin,silica gel,Sephadex LH-20,and C18-reversed-phase column chromatography. A new spirocyclic cycloartane triterpenoid was isolated and identified as( 16 R*,20 R*,23 S*,24 R*,25 S*)-16,23 23,26-diepoxy-15α,24,25-trihydroxy-9,19-cycloart-3β-O-β-D-xylopyranoside( 1),and named as soulieoside S. Its planar structure and relative configuration were determined by spectroscopic techniques including 2 D NMR and HRESI-MS. As one of the main components of S. vaginata,compound 1 was evaluated for its anti-inflammatory activity by a lipopolysaccharide( LPS)-stimulated NO production model in RAW264. 7 macrophages,but it didn't show NO production inhibitory effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triterpenes
/
Molecular Structure
/
Lipopolysaccharides
/
Actaea
/
Glycosides
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2019
Type:
Article
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