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Untargeted metabonomics study of ginseng in treatment of spleen-Qi deficiency / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 398-404, 2020.
Article in Chinese | WPRIM | ID: wpr-1008350
ABSTRACT
Ginseng has been used to treat Qi-deficiency syndrome up to now, while the therapeutic mechanism is still unclear. In order to explore the mechanism of ginseng in the treatment of Qi-deficiency constitution, the untargeted metabonomics with blood was studied based on rapid resolution high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(RRLC-Q-TOF-MS). In the results, 13 potential biomarkers were found and identified, which mainly involved in the body's antioxidant and immune functions and energy, glycerol, fatty acid, sugar metabolism and bile acid metabolism. The results of blood biochemical analysis also indicated that ginseng could regulate the body's energy metabolism, immune functions and antioxidant capacity in spleen-Qi deficiency constitution. This study revealed the mechanism of ginseng in the treatment of spleen-Qi deficiency using the blood metabonomics, which could provide technological support and scientific basis for further research on ginseng treatment of Qi-deficiency.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spleen / Drugs, Chinese Herbal / Biomarkers / Chromatography, High Pressure Liquid / Qi / Energy Metabolism / Metabolomics / Panax / Immune System / Medicine, Chinese Traditional Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spleen / Drugs, Chinese Herbal / Biomarkers / Chromatography, High Pressure Liquid / Qi / Energy Metabolism / Metabolomics / Panax / Immune System / Medicine, Chinese Traditional Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2020 Type: Article