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Analysis and health risk assessment of aflatoxin B_1 residue in Ziziphi Spinosae Semen / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 5078-5082, 2019.
Article in Chinese | WPRIM | ID: wpr-1008366
ABSTRACT
This study aimed to analyze the residues of aflatoxin B_1( AFB_1) in Ziziphi Spinosae Semen from different producing areas and to assess the health risk of aflatoxin B_1 residue based on the obtained data. A total of 72 samples of Ziziphi Spinosae Semen from different areas were detected by IAC-HPLC-FLD. Based on the data of AFB_1 pollution,a probabilistic assessment model with Monte Carlo simulation was developed. Then,the risk assessment of AFB_1 exposure by Ziziphi Spinosae Semen intake was carried out by MOE( margin of exposure). The results showed that 32 out of 72 of samples( 44. 4%) were found to be contaminated with AFB_1,and the average and maximum concentration of AFB_1 in samples was 5. 42 μg·kg~(-1) and 55. 09 μg·kg~(-1),respectively. After health risk assessment,the average and 97. 5%( 90% confidence interval) exposure level of daily exposure of AFB_1 by Ziziphi Spinosae Semen intake were 0. 008 6( 0. 008 1-0. 009 2) and 0. 057 3( 0. 053 2-0. 061 4) μg·kg~(-1)·d~(-1),respectively. The results showed common use of Ziziphi Spinosae Semen had low level of risk associated with AFB_1. However,the high consumption of Ziziphi Spinosae Semen showed a higher risk than common intake,requiring attention. This study laid a foundation for clinical safe prescription of Ziziphi Spinosae Semen.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Drug Contamination / Chromatography, High Pressure Liquid / Aflatoxin B1 / Risk Assessment / Plant Preparations / Ziziphus Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Drug Contamination / Chromatography, High Pressure Liquid / Aflatoxin B1 / Risk Assessment / Plant Preparations / Ziziphus Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article